NPD11033 | SIRT2 inhibitor | Probechem Biochemicals

Chemical Structure : NPD11033

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NPD11033 (NPD-11033)

货号: PC-24697Not For Human Use, Lab Use Only.

NPD11033 is a potent, selective, and cellular effective SIRT2 inhibitor with IC50 of 0.46 uM, inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.

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生物&药学活性

NPD11033 is a potent, selective, and cellular effective SIRT2 inhibitor with IC50 of 0.46 uM, inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
NPD11033 has only a marginal effect on other human sirtuin members including SIRT1 and SIRT3, also does not inhibit enzymatic activities of zinc-dependent HDACs, such as HDAC1 and HDAC6.
NPD11033 is a useful tool for both developing novel anti-cancer agents and elucidating the role of SIRT2 in various cellular biological processes.

物理化学性质&存储条件

分子量	480.69
分子式	C30H44N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,5S)-3-(3-(2,4-di-tert-pentylphenoxy)-2-hydroxypropyl)-1,2,3,4,5,6-hexahydro-10H-1,5-methanopyrido[1,2-d][1,4]diazocin-10-one

参考文献

1. Norio Kudo, et al. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170070.

NPD11033 (NPD-11033)

生物&药学活性

物理化学性质&存储条件

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NPD11033 (NPD-11033)

生物&药学活性

物理化学性质&存储条件

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