NPC-15437 | PKC inhibitor | Probechem Biochemicals

Chemical Structure : NPC-15437

CAS No.: 141774-20-1

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NPC-15437 (NPC 15437, NPC15437)

货号: PC-27152Not For Human Use, Lab Use Only.

NPC-15437 (NPC15437) is a specific, competitive small molecule protein kinase C (PKC) inhibitor with IC50 of 19 uM.

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5 mg	￥3780	In stock
10 mg	￥5780	In stock
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生物&药学活性

NPC-15437 (NPC15437) is a specific, competitive small molecule protein kinase C (PKC) inhibitor with IC50 of 19 uM.
NPC-15437 inhibits activation of PKCα by both phorbol 12-myristate 13-acetate (PMA) (Ki = 5 uM) and phosphatidylserine (PS) (Ki = 12 uM).
NPC-15437 inhibits phorbol ester-induced ear edema in mouse (IC50 = 175 micrograms/ear), demonstrating the ability to inhibit PKC-mediated activity in intact cells.
NPC-15437 (1 mg/kg) induces specific deficits in memory retention in mice.

物理化学性质&存储条件

分子量	511.62
分子式	C25H52Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2,6-Diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]-hexanamide, dihydrochloride

参考文献

1. Sha EC, et al. Invest New Drugs. 1996;13(4):285-94.

2. Mathis C, et al. Eur J Pharmacol. 1992 Sep 10;220(1):107-10.

3. Sullivan JP, et al. Mol Pharmacol. 1992 Jan;41(1):38-44.

4. Sullivan JP, et al. Agents Actions. 1991 Sep;34(1-2):142-4.

NPC-15437 (NPC 15437, NPC15437)

生物&药学活性

物理化学性质&存储条件

参考文献

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NPC-15437 (NPC 15437, NPC15437)

生物&药学活性

物理化学性质&存储条件

参考文献

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