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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NADPH Oxidase (NOX)-NOX4 inhibitor 18
NOX4 inhibitor 18

Chemical Structure : NOX4 inhibitor 18

CAS No.:

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NOX4 inhibitor 18

货号: PC-27679Not For Human Use, Lab Use Only.

NOX4 inhibitor 18 is a first-in-class homolog-selective, covalent NOX4 inhibitor with IC50 of 3.1 uM, IC50 app of 0.42 uM for NOX4 dehydrogenase domain, show no activity against NOX1,2,5 (IC50>100 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NOX4 inhibitor 18 is a first-in-class homolog-selective, covalent NOX4 inhibitor with IC50 of 3.1 uM, IC50 app of 0.42 uM for NOX4 dehydrogenase domain, show no activity against NOX1,2,5 (IC50>100 uM).

物理化学性质&存储条件

分子量 349.35
分子式 C17H15N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(((3-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)methyl)benzyl)-1H-pyrrole-2,5-dione

参考文献

1. Castelôa M, et al. Biomed Pharmacother. 2026 Aug 14;203:119844.

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