NNZ-2591 | Neuroprotective agent | Probechem Biochemicals

Chemical Structure : NNZ-2591

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NNZ-2591 (Ercanetide, cyclo-L-glycyl-L-2-allylproline)

货号: PC-25050Not For Human Use, Lab Use Only.

Ercanetide (NNZ-2591, NNZ 2591) is an analogue of endogenous diketopiperazine cyclo-glycyl-proline (cyclic GP), shows neuroprotective effect.

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生物&药学活性

Ercanetide (NNZ-2591, NNZ 2591) is an analogue of endogenous diketopiperazine cyclo-glycyl-proline (cyclic GP), shows neuroprotective effect.
Central administration of NNZ 2591 reduced the extent of brain damage in the lateral cortex, the hippocampus and the striatum in hypoxic-ischemic injured rats.
NNZ-2591 significantly improved motor function after hypoxic-ischaemic brain injury in rats.
NNZ-2591 significantly enhanced the expression of doublecortin-positive neuroblasts in the sub-ventricular zone
NNZ-2591 also improves motor function in a rat model of Parkinson's disease.

物理化学性质&存储条件

分子量	194.23
分子式	C10H14N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-8a-allylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

参考文献

1. Krishnamurthi RV, et al. Br J Pharmacol. 2009 Feb;156(4):662-72.

2. Guan J, et al. Neuropharmacology. 2007 Nov;53(6):749-62.

NNZ-2591 (Ercanetide, cyclo-L-glycyl-L-2-allylproline)

生物&药学活性

物理化学性质&存储条件

参考文献

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NNZ-2591 (Ercanetide, cyclo-L-glycyl-L-2-allylproline)

生物&药学活性

物理化学性质&存储条件

参考文献

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