NNRTI compound 5i3

Chemical Structure : NNRTI compound 5i3

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货号: PC-24720Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

NNRTI compound 5i3 is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), shows potent antiviral activity against NNRTI-resistant strains (GH9, p1579, p5375, p1833, and p5735) with EC50 of 2.6-18.3 nM.
5i3 shows antiviral efficacy comparable to RPV with an EC50 value of 1.16 nM against HIV-1 (NL4-3).
5i3 has antiviral potency of 5i3 against the GH9 strain (EC50 = 11.1 nM), which is about 9.4-fold higher than ETR and 154-fold higher than RPV.
5i3 suppresses the replication of HIV-1 IIIB very effectively at single-digit nanomolar levels (EC50 =1.4 nM).
5i3 as an orally bioavailable NNRTI drug candidate.

物理化学性质&存储条件

分子量	568.70
分子式	C31H32N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3,5-dimethyl-4-((2-((1-(4-(methylsulfonyl)benzyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile

参考文献

1. Zhao Wang, et al. Sci Adv. 2025 May 30;11(22):eadt8916.