NNC-711 | GAT-1 inhibitor | Probechem Biochemicals

Chemical Structure : NNC-711

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NNC-711 (NNC711)

货号: PC-62931Not For Human Use, Lab Use Only.

NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.

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生物&药学活性

NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.
NNC-711 displays excellent selectivty over rGAT-2, hGAT-3 and hBGT-1, and other other neurotransmitter receptors.
NNC-711 inhibits synaptosomal (IC50=47 nM), neuronal (IC50=1238 nM) and glial (IC50=636 nM) GABA uptake in vitro.
NNC-711 demonstrates potent anticonvulsant activity against rodent seizures induced by DMCM.

物理化学性质&存储条件

分子量	386.876
分子式	C21H23ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride

参考文献

1. Suzdak PD, et al. Eur J Pharmacol. 1992 Dec 2;224(2-3):189-98.

2. Oh DJ, et al. Epilepsia. 1994 Mar-Apr;35(2):426-30.

3. Borden LA, et al. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

NNC-711 (NNC711)

生物&药学活性

物理化学性质&存储条件

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NNC-711 (NNC711)

生物&药学活性

物理化学性质&存储条件

参考文献

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