欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-NN-01-195
NN-01-195

Chemical Structure : NN-01-195

CAS No.:

加入收藏

NN-01-195

货号: PC-26261Not For Human Use, Lab Use Only.

NN-01-195 is a chimeric small molecule conjugate of HSP90 and AURKA inhibitor, tightly binds and inhibits both AURKA and HSP90 with IC50 of 3.1 nM and 8.1 nM in biochemical assays.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NN-01-195 is a chimeric small molecule conjugate of HSP90 and AURKA inhibitor, tightly binds and inhibits both AURKA and HSP90 with IC50 of 3.1 nM and 8.1 nM in biochemical assays.
NN-01-195 combines an AURKA inhibitor related to TAS-119/VIC-1911 with an HSP90-binding moiety related to SNX2112.
NN-01-195 causes mitotic arrest and spindle abnormalities and a profile of signaling changes that closely resembles that of an AURKA inhibitor.
NN-01-195 reduces cell viability and promotes mitotic abnormalities.
NN-01-195 elevates apoptosis and reduces cell viability for human papillomavirus–negative HNSCC (FaDu, Detroit 562, and Cal27), NSCLC (H1975, PC9), and melanoma (WM3000, WM33451) models with IC50 of 0.27-2.98 uM.
NN-01-195 (10 mg/kg, IP) is highly effective at controlling xenograft tumor volume in FaDu cells xenografted onto NSG mice.

物理化学性质&存储条件

分子量 1128.07
分子式 C56H60Cl2F4N12O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-(4-(4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)phenyl)piperazin-1-yl)-6-oxohexyl)-1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyridin-2-yl)methyl)piperidine-4-carboxamide

参考文献

1. Nguyen TT, et al. Mol Cancer Ther. 2026 Jan 23. doi: 10.1158/1535-7163.MCT-25-0857.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: