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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-NMS-859
NMS-859

Chemical Structure : NMS-859

CAS No.: 1449236-96-7

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NMS-859 (NMS859)

货号: PC-26296Not For Human Use, Lab Use Only.

NMS-859 is a covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 0.37 uM, covalently modifies VCP on the active site Cys522 and blocks ATP binding.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NMS-859 is a covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 0.37 uM, covalently modifies VCP on the active site Cys522 and blocks ATP binding.

物理化学性质&存储条件

分子量 349.79
分子式 C15H12ClN3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide

参考文献

1. Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56.

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