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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-NLX-266
NLX-266

Chemical Structure : NLX-266

CAS No.: 2170564-20-0

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NLX-266 (NLX266)

货号: PC-24462Not For Human Use, Lab Use Only.

NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors.
NLX-266 preferentially activates ERK1/2 phosphorylation, correlating with significant antidepressant effects in the forced swim test in rats at low doses (MED = 0.63 mg/kg p.o.).
NLX-266 demonstrates potent antiparkinsonian effects by reversing haloperidol-induced catalepsy at very low doses (MED = 0.04 mg/kg p.o.). 

物理化学性质&存储条件

分子量 427.85
分子式 C20H21ClF3N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-Chloro-4-fluorophenyl)(4-fluoro-4-(((2-((4-fluoropyridin-2-yl)oxy)ethyl)amino)methyl)piperidin-1-yl)methanone

参考文献

1. Sniecikowska J, et al. J Med Chem. 2025 Apr 23. doi: 10.1021/acs.jmedchem.5c00484.

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