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首页-小分子抑制剂&激动剂-GPCR-Histamine Receptor-NLX-204
NLX-204

Chemical Structure : NLX-204

CAS No.: 2170405-10-2

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NLX-204 (NLX204, NLX 204)

货号: PC-36071Not For Human Use, Lab Use Only.

NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.
    NLX-204  shows promising pharmacokinetic profile, also robustly stimulates ERK1/2 phosphorylation in rat cortex and showed highly potent (MED=0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.

    物理化学性质&存储条件

    分子量 409.862
    分子式 C20H22ClF2N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-chloro-4-fluorophenyl)(4-fluoro-4-(((2-(pyridin-2-yloxy)ethyl)amino)methyl)piperidin-1-yl)methanone

    参考文献

    1. Sniecikowska J, et al. J Med Chem. 2019 Feb 5. doi: 10.1021/acs.jmedchem.9b00062.

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