NK7-902

Chemical Structure : NK7-902

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货号: PC-24938Not For Human Use, Lab Use Only.

NK7-902 is a potent and selective cereblon (CRBN) glue degrader of NEK7 with DC50 of 0.2 nM in human primary monocytes (Dmax>95%).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

NK7-902 is a potent and selective cereblon (CRBN) glue degrader of NEK7 with DC50 of 0.2 nM in human primary monocytes (Dmax>95%).
NK7-902 inhibits the NLRP3 inflammasome in human primary monocytes, selectively blocks both canonical and alternative NLRP3 pathway activation in vitro.
NK7-902 partially inhibits NLRP3-dependent IL-1β release in human PMBCs and whole blood.
NK7-902 degrades NEK7 in mouse cells and in mice.
NK7-902 causes lasting NEK7 degradation in primates, but transient NLRP3 inhibition.

物理化学性质&存储条件

分子量	410.47
分子式	C22H26N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dioxopiperidin-3-yl)-5-((1S,2R,5S)-2-(ethylamino)-8-azabicyclo[3.2.1]octan-8-yl)isoindoline-1,3-dione

参考文献

1. Sylvain A, et al. Cell Chem Biol. 2025 Jul 7:S2451-9456(25)00200-4.

NK7-902

生物&药学活性

物理化学性质&存储条件

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NK7-902

生物&药学活性

物理化学性质&存储条件

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