NGD94-1 | Dopamine D4 receptor antagonist | Probechem Biochemicals

Chemical Structure : NGD94-1

加入收藏

NGD94-1 (NGD 94-1)

货号: PC-27156Not For Human Use, Lab Use Only.

NGD94-1 (NGD 94-1) is a potent and selective dopamine D4 receptor (D4R) antagonist with Ki of 3.6 nM for cloned human D4.2 receptor.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NGD94-1 (NGD 94-1) is a potent and selective dopamine D4 receptor (D4R) antagonist with Ki of 3.6 nM for cloned human D4.2 receptor.
NGD94-1 (NGD 94-1) displays >600-fold selectivity for D4.2 receptor subtype compared with a wide variety of monoamine or other neurotransmitter receptor or modulatory sites except for 5-HT1A and 5-HT3 receptors.
NGD94-1 (NGD 94-1) is also an agonist in human embryonic kidney 293 cells expressing human recombinant dopamine D4.4 receptors.
NGD 94-1 completely reversed the decrease in forskolin-stimulated cAMP levels produced by the dopamine receptor full agonist quinpirole.
NGD94-1 (NGD 94-1) reverses subchronic phencyclidine-induced object retrieval/detour deficits in vivo.

物理化学性质&存储条件

分子量	320.40
分子式	C18H20N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-((2-Phenyl-1H-imidazol-5-yl)methyl)piperazin-1-yl)pyrimidine

参考文献

1. J D Jentsch, et al. Psychopharmacology (Berl). 1999 Feb;142(1):78-84.

2. Gazi L, et al. Eur J Pharmacol. 1999 May 21;372(3):R9-10.

3. Tallman JF, et al. J Pharmacol Exp Ther. 1997 Aug;282(2):1011-9.

NGD94-1 (NGD 94-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NGD94-1 (NGD 94-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.