NEDD4 inhibitor 32

Chemical Structure : NEDD4 inhibitor 32

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货号: PC-24781Not For Human Use, Lab Use Only.

NEDD4 inhibitor 32 is a selective, covalent inhibitor of E3 ubiquitin ligases NEDD4 with IC50 of 0.12 uM, specifically target the non-catalytic cysteine C627, effectively inhibits NEDD4-mediated polyubiquitination.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NEDD4 inhibitor 32 is a selective, covalent and cell-active inhibitor of E3 ubiquitin ligases NEDD4 with IC50 of 0.12 uM, specifically target the non-catalytic cysteine C627, effectively inhibits NEDD4-mediated polyubiquitination.

物理化学性质&存储条件

分子量	369.90
分子式	C20H24ClN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((4-(8-chloro-1-methyl-4,5-dihydrobenzo[b]pyrazolo[4,3-f]azepin-10(1H)-yl)butyl)amino)but-2-enenitrile

参考文献

1. Maspero E, et al. Commun Chem. 2025 May 28;8(1):164.