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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-NDNA4
NDNA4

Chemical Structure : NDNA4

CAS No.: 3054414-96-6

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NDNA4

货号: PC-26414Not For Human Use, Lab Use Only.

NDNA4 is a potent, selective and cell-impermeable Hsp90α inhibitor with IC50 of 0.34 uM in FP assays, >294-fold selective over Hsp90β, Grp94 and Trap1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NDNA4 is a potent, selective and cell-impermeable Hsp90α inhibitor with IC50 of 0.34 uM in FP assays, >294-fold selective over Hsp90β, Grp94 and Trap1.

物理化学性质&存储条件

分子量 604.69
分子式 C31H35F3N2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Propanaminium, 3-[[2-[3-[(3,4-dimethylphenyl)thio]-4-hydroxybenzoyl]-2,3-dihydro-1H-isoindol-5-yl]oxy]-N,N,N-trimethyl-, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Reynolds TS, et al. ACS Med Chem Lett. 2023 Aug 8;14(9):1250-1256.

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