NCX inhibitor SN-6 | NCX inhibitor | Probechem Biochemicals

Chemical Structure : NCX inhibitor SN-6

CAS No.: 415697-08-4

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NCX inhibitor SN-6 (SN6)

货号: PC-25194Not For Human Use, Lab Use Only.

SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, inhibits Ca2+ uptake by NCX1, NCX2, and NCX3 with IC50 of 2.9, 16, and 8.6 uM, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
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生物&药学活性

SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, inhibits Ca2+ uptake by NCX1, NCX2, and NCX3 with IC50 of 2.9, 16, and 8.6 uM, respectively.
SN-6 (0.3-30 uM) inhibits preferentially intracellular Na(+)-dependent (45)Ca(2+) uptake (i.e., the reverse mode) compared with extracellular Na(+)-dependent (45)Ca(2+) efflux (i.e., the forward mode) in NCX1-transfected fibroblasts.
SN-6 is 3- to 5-fold more inhibitory to (45)Ca(2+) uptake in NCX1 (IC(50) = 2.9 uM) than to that in NCX2 or NCX3 but not to that in NCKX2.
SN-6 at lower doses (IC(50) = 0.63 uM) potently protects against hypoxia/reoxygenation-induced cell damage in renal tubular cells overexpressing NCX1, suggesting that this drug predominantly works under hypoxic/ischemic conditions.

物理化学性质&存储条件

分子量	402.47
分子式	C20H22N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate

参考文献

1. Iwamoto T, et al. Mol Pharmacol. 2004 Jul;66(1):45-55.

NCX inhibitor SN-6 (SN6)

生物&药学活性

物理化学性质&存储条件

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NCX inhibitor SN-6 (SN6)

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物理化学性质&存储条件

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