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首页-小分子抑制剂&激动剂-Others-Other Targets-NCI-41356
NCI-41356

Chemical Structure : NCI-41356

CAS No.: 910548-20-8

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NCI-41356 (NCI 41356)

货号: PC-20883Not For Human Use, Lab Use Only.

NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165.
NCI-41356 (10-50 uM) decreases the malignant behaviour of breast tumour cells MDA-MB-231 and MDA-MB-436, does not alter CRYAB expression levels.
NCI-41356 (200 mg/kg, i.p.) greatly inhibits the tumour growth and vasculature development in in vivo human breast cancer xenograft models.

物理化学性质&存储条件

分子量 197.62
分子式 C6H12ClNO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,3R)-3-methylglutamic acid hydrochloride

参考文献

1. Chen Z, et al. Breast Cancer Res Treat. 2014 May;145(1):45-59.

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