NCH-51 |CAS:848354-66-5 Probechem Biochemicals

Chemical Structure : NCH-51

CAS No.: 848354-66-5

加入收藏

NCH-51 (NCH51)

货号: PC-43291Not For Human Use, Lab Use Only.

NCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1, inhibits cell proliferation of NCI-H460 and MDA-MB-231 with IC50 of 2.1 and 4.4 uM.

规格	价格	库存
5 mg	￥780	In stock
25 mg	￥1980	In stock
100 mg	￥4880	In stock
250 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1, inhibits cell proliferation of NCI-H460 and MDA-MB-231 with IC50 of 2.1 and 4.4 uM。
NCH-51 inhibits the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA, upregulates p21 and downregulated anti-apoptotic molecules including survivin, bcl-w and c-FLIP.
NCH-51 also induces expression of latent HIV-1 through the Sp1 sites with minimal cytotoxicit in latently infected-cells.

物理化学性质&存储条件

分子量	390.5627
分子式	C20H26N2O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Propanethioic acid, 2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester

参考文献

1. Sanda T, et al. Leukemia. 2007 Nov;21(11):2344-53.

2. Suzuki T, et al. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1558-61.

3. Suzuki T, et al. J Med Chem. 2005 Feb 24;48(4):1019-32.

4. Victoriano AF, et al. FEBS Lett. 2011 Apr 6;585(7):1103-11.

NCH-51 (NCH51)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NCH-51 (NCH51)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.