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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-NCGC00247743
NCGC00247743

Chemical Structure : NCGC00247743

CAS No.: 1435192-04-3

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NCGC00247743

货号: PC-26949Not For Human Use, Lab Use Only.

NCGC00247743 is a selective inhibitor of histone lysine demethylase KDM4/JMJD2s with IC50 of 10 nM for KDM4B, inhibits LNCaP cell growth with IC50 in the μM range, shows no or weak activity for KDM5A/JARID1A.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NCGC00247743 is a selective inhibitor of histone lysine demethylase KDM4/JMJD2s with IC50 of 10 nM for KDM4B, inhibits LNCaP cell growth with IC50 in the μM range, shows no or weak activity for KDM5A/JARID1A.

物理化学性质&存储条件

分子量 391.52
分子式 C24H29N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-(dimethylamino)hexyl)-3-(8-hydroxyquinolin-6-yl)benzamide

参考文献

1. Duan L, et al. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol. 2015 Sep 17;22(9):1185-96.

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