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首页-小分子抑制剂&激动剂-Others-Pyruvate Kinase-NCGC00188636
NCGC00188636

Chemical Structure : NCGC00188636

CAS No.: 1039980-33-0

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NCGC00188636 (DBS)

货号: PC-26938Not For Human Use, Lab Use Only.

NCGC00188636 (DBS) is a covalent inhibitor of pyruvate kinase (PYK) with IC50 of Leishmania mexicana PYK (LmPYK), inhibits both HsRPYK (the human PYK isoenzyme present in erythrocytes) and HsM2PYK (the human PYK isoenzyme present in embryonic and tumour cells) with IC50 values of 8 uM and 16.3 uM, respectively.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NCGC00188636 (DBS) is a covalent inhibitor of pyruvate kinase (PYK) with IC50 of Leishmania mexicana PYK (LmPYK), inhibits both HsRPYK (the human PYK isoenzyme present in erythrocytes) and HsM2PYK (the human PYK isoenzyme present in embryonic and tumour cells) with IC50 values of 8 uM and 16.3 uM, respectively.
NCGC00188636 (DBS) blocks nucleotide binding to the active site of pyruvate kinase, reacts with Lys335 at the active site of LmPYK.

物理化学性质&存储条件

分子量 319.35
分子式 C14H9NO4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[(1,1-dioxo-1,2-benzothiazol-3-yl)sulfanyl]benzoic acid

参考文献

1. Hugh P Morgan, et al. Biochem J. 2012 Nov 15;448(1):67-72.

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