NCBP1

Chemical Structure : NCBP1

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货号: PC-24346Not For Human Use, Lab Use Only.

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生物&药学活性

NCBP1 is a plant-derived, 11 amino acid, noncanonical antibacterial peptide with dual activity against multidrug-resistant bacterial and fungal pathogens, by targeting phosphatidylglycerol and cardiolipin in bacterial membrane, resulting in membrane damage and dysfunction.
NCBP1 showed antibacterial activity (MIC, 16-64 uM) against a panel of Staphylococcus spp. strains from animals, including methicillin-resistant S. aureus, S. chromogenes, S. equorum, S. intermedius, S. lentus, S. simulans, and S. squirrel.
NCBP1 displayed bactericidal activity by targeting bacterial membrane.
NCBP1 exhibits a high binding affinity to phosphatidylglycerol (PG) with SPR Kd of 5.34 uM, as well as and cardiolipin (CL), but no binding for phosphatidylethanolamine (PE).
NCBP1 may trigger membrane disruption, leading to the loss of membrane potential, ATP leakage, and ROS accumulation.
NCBP1 protected mice from S. cohnii infection, enhances resistance to fungal diseases in maize plants.

物理化学性质&存储条件

分子量	1239.55
分子式	C58H94N16O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sequence: Lys-Pro-Trp-Leu-Arg-Val-Ala-Leu-Cys-Pro-Gly

参考文献

1. Chen X, et al. Sci Adv. 2025 Mar 21;11(12):eadt8239.

NCBP1

生物&药学活性

物理化学性质&存储条件

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NCBP1

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物理化学性质&存储条件

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