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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-TNIK-NCB-0846
NCB-0846

Chemical Structure : NCB-0846

CAS No.: 1792999-26-8

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NCB-0846 (NCB 0846, NCB0846)

货号: PC-42270Not For Human Use, Lab Use Only.

NCB-0846 (NCB0846) is the first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NCB-0846 (NCB0846) is the first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM.
NCB-0846 also weakly inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK (IC80>0.1 uM).
NCB-0846 induces faster migration of TCF4 phosphorylated by TNIK at 0.1-0.3 uM, and completely inhibits at 3 uM; also reduces the expression of TNIK, AXIN2, cMYC, LRP6 and LRP5.
NCB-0846 abrogates colorectal cancer stemness, suppresses Wnt-driven intestinal tumorigenesis in Apc(min/+) mice.

物理化学性质&存储条件

分子量 375.4237
分子式 C21H21N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

Cyclohexanol, 4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-, cis-

参考文献

1. Masuda M, et al. Nat Commun. 2016 Aug 26;7:12586.

2. Yamada T, et al. Cancer Sci. 2017 May;108(5):818-823.

3. Mahmoudi T, et al. EMBO J. 2009 Nov 4;28(21):3329-40.

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