NAV-2729 | ARF6 inhibitor | Probechem Biochemicals

Chemical Structure : NAV-2729

CAS No.: 419547-11-8

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NAV-2729 (NAV2729)

货号: PC-60611Not For Human Use, Lab Use Only.

NAV-2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

NAV-2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays.
NAV 2729 shows no inhibitory effects for all other human ARF family members, as well as other small GTPases, such as RhoA, Rac1, H-Ras, and Cdc42 (IC50>50 uM).
NAV 2729 inhibits all known signaling pathways downstream of oncogenic GNAQ in uveal melanoma cells, including PLC/PKC, Rho/Rac, YAP, and β-catenin.
NAV 2729 reduces uveal melanoma cell proliferation and tumorigenesis in mouse models.

物理化学性质&存储条件

分子量	456.886
分子式	C25H17ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-benzyl-3-(4-chlorophenyl)-5-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

参考文献

1. Yoo JH, et al. Cancer Cell. 2016 Jun 13;29(6):889-904.

2. Benabdi S, et al. Biochemistry. 2017 Sep 26;56(38):5125-5133.

NAV-2729 (NAV2729)

生物&药学活性

物理化学性质&存储条件

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NAV-2729 (NAV2729)

生物&药学活性

物理化学性质&存储条件

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