N-Myc inhibitor N78

Chemical Structure : N-Myc inhibitor N78

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货号: PC-25463Not For Human Use, Lab Use Only.

N-Myc inhibitor N78 is a selective small molecule inhibitor of N-Myc with MST binding Kd of 1.47 uM, 6-fold selective over c-Myc, inhibits viability of MYCN-dependent tumor cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

N-Myc inhibitor N78 is a selective small molecule inhibitor of N-Myc with MST binding Kd of 1.47 uM, 6-fold selective over c-Myc, inhibits viability of MYCN-dependent tumor cells.
N78 markedly inhibits MYCN-Gal4BD luciferase activity at 1 μM, with no effect on CREB-Gal4BD luciferase activity, also not inhibit c-MYC-Gal4BD luciferase activity.
N78 selectively inhibits cells growth of N-Myc expression of N-Myc-dependent neuroblastoma cells.
N78 selectively inhibits N-Myc expression, with greater selectivity and potency than MYCi975, does not effectively suppress c-Myc expression in TNBC cells.
N78 decreases N-Myc protein stability by regulating phosphorylation of N-Myc at threonine 58 (Thr58), leading to subsequent degradation via the proteasome pathway.
N78 (10 mg/kg/d and 20 mg/kg/d) significantly suppressed tumor growth with Tumor growth inhibition (TGI) values of 79.4% and 61.4%, respectively, in neuroblastoma SK-N-BE (2) subcutaneous xenograft model, showing decreased levels of Ki67 and N-Myc in tumor tissues.

物理化学性质&存储条件

分子量	361.20
分子式	C15H13BrN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-bromo-N-(2-(4-methoxyphenyl)-2H-benzo[d][1,2,3]triazol-5-yl)acetamide

参考文献

1. Miao Y, et al. Int J Biol Sci. 2025 Jul 28;21(11):4895-4907.