N-19004 | FPR1 antagonist | Probechem Biochemicals

Chemical Structure : N-19004

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N-19004 (N19004)

货号: PC-25276Not For Human Use, Lab Use Only.

N-19004 is a potent, specific formyl peptide receptor (FPR1) antagonist with IC50 of 68.9 nM for inhibition of the binding of FITC-fMLF to THP-1 cells.

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生物&药学活性

N-19004 is a potent, specific formyl peptide receptor (FPR1) antagonist with IC50 of 68.9 nM for inhibition of the binding of FITC-fMLF to THP-1 cells.
N-19004 hampers THP-1 cell migration triggered by the CCL2 chemokine in a dose-dependent manner (IC50=10 nM).
N-19004 (20 mg/kg) effectively reduced the lesion extravasation area, improved edema resorption by a systemic administration route in mouse model of choroidal neovascularization (CNV).

物理化学性质&存储条件

分子量	562.74
分子式	C29H38N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-(5-(tert-butyl)-2-((naphthalen-2-ylmethyl)thio)-1,3-phenylene)bis(3-((diaminomethylene)amino)propanamide)

参考文献

1. De Fenza M, et al. ACS Pharmacol Transl Sci. 2024 Oct 23;7(11):3476-3487.

N-19004 (N19004)

生物&药学活性

物理化学性质&存储条件

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N-19004 (N19004)

生物&药学活性

物理化学性质&存储条件

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