N-0920 | TMPRSS2 inhibitor | Probechem Biochemicals

Chemical Structure : N-0920

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N-0920 (Cbz-QFR-kt)

货号: PC-24517Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

N-0920 (Cbz-QFR-kt) is highly potent, specific TMPRSS2 inhibitor with IC50 of 350 pM, displays high antiviral potency with IC50 of 0.3 nM and 0.09 nM for SARS-CoV-2 Variants EG.5.1 and JN.1 respectively.
N-0920 demonstrates strong inhibitory properties with a Ki of 0.03 nM against in vitro dasTMPRSS2.
N-0920 is 533-fold more selective for TMPRSS2 over FXa, 36-fold selectivity for TMPRSS2 over matriptase and low potency against TMPRSS13, also doest not inhibit Cathepsin L.
N-0920 does not impact the SARS-CoV-2 endocytosis/cathepsin entry pathway or, to a greater extent, a TMPRSS2-independent entry pathway.

物理化学性质&存储条件

分子量	650.76
分子式	C31H38N8O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl ((S)-5-amino-1-(((S)-1-(((S)-5-guanidino-1-oxo-1-(thiazol-2-yl)pentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)carbamate

参考文献

1. Lemieux G, et al. J Med Chem. 2025 Apr 10;68(7):7119-7136.

N-0920 (Cbz-QFR-kt)

生物&药学活性

物理化学性质&存储条件

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N-0920 (Cbz-QFR-kt)

生物&药学活性

物理化学性质&存储条件

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