Myriocin (ISP-1) | Serine palmitoyltransferase inhibitor

Chemical Structure : Myriocin

CAS No.: 35891-70-4

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Myriocin (ISP-1, Thermozymocidin)

货号: PC-61423Not For Human Use, Lab Use Only.

Myriocin (ISP-1) is an amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.

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10 mg	￥2980	In stock
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生物&药学活性

Myriocin (ISP-1) is an amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.
Myriocin (ISP-1) is a potent inhibitor of serine palmitoyltransferase (SPT) with Ki of 0.28 nM.
Myriocin (ISP-1) inhibits the proliferation of IL-2-dependent mouse cytotoxic T cell line CTLL-2 (IC50=15 nM) by the modulation of sphingolipid metabolism.

物理化学性质&存储条件

分子量	401.5
分子式	C21H39NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid

参考文献

1. Fujita T, et al. J Antibiot (Tokyo). 1994 Feb;47(2):208-15.

2. Miyake Y, et al. Biochem Biophys Res Commun. 1995 Jun 15;211(2):396-403.

3. Nakamura S, et al. J Biol Chem. 1996 Jan 19;271(3):1255-7.

Myriocin (ISP-1, Thermozymocidin)

生物&药学活性

物理化学性质&存储条件

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Myriocin (ISP-1, Thermozymocidin)

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