Myc modulator DL78

Chemical Structure : Myc modulator DL78

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货号: PC-25645Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Myc modulator DL78 is a small molecule Myc modulator and potent antimitotic agent with selective anticancer activity, disrupts Myc and α-tubulin interaction and preferentially targets chromosomally unstable, MYC-overexpressing cancer cells.
DL78 sensitizes platinum-resistant cells to cisplatin and induces apoptosis following mitotic catastrophe.
High Myc-expressing cancer cells are selectively sensitive to DL78.
DL78 (50 mg/kg IP) significantly decreased overall tumor burden and metastatic spread in NSG mice injected intraperitoneally with OV81.2 cells.
DL78 induces cancer-selective mitotic catastrophe by disrupting Myc's interaction with α-tubulin rather than its transcriptional activity.

物理化学性质&存储条件

分子量	336.34
分子式	C20H16O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-methoxy-2-methylbenzofuran-3-yl)(5-methoxybenzofuran-2-yl)methanone

参考文献

1. Teitel J, et al. Sci Rep. 2025 Oct 31;15(1):38188.