MyD88 inhibitor C17 | MyD88 inhibitor | Probechem Biochemicals

Chemical Structure : MyD88 inhibitor C17

CAS No.: 2911609-80-6

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MyD88 inhibitor C17 (MyD88-IN-1)

货号: PC-21177Not For Human Use, Lab Use Only.

MyD88 inhibitor C17 is a highly potent inhibitor of myeloid differentiation primary response protein 88 (MyD88), dose-dependently inhibits LPS-induced IL-6 and TNF-α in J774A.1 macrophages with IC50 of 2.17 and 8.17 uM, respectively.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

MyD88 inhibitor C17 is a highly potent inhibitor of myeloid differentiation primary response protein 88 (MyD88), dose-dependently inhibits LPS-induced IL-6 and TNF-α in J774A.1 macrophages with IC50 of 2.17 and 8.17 uM, respectively.
MyD88 inhibitor C17 directly interacts with MyD88 in a dose-dependent manner with Kd of 53 uM in SPR assays.
MyD88 inhibitor C17 also shows inhibition on the release of cytokines in LPS-stimulated human THP-1 cells, suppresses TLR-MyD88 signaling in response to LPS stimulation.
MyD88 inhibitor C17 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway.
MyD88 inhibitor C17 treatment (20 mg/kg, orally) led to the accumulation in the lungs of rats and attenuated LPS-induced ALI mice model, with negligible toxicity in vivo.

物理化学性质&存储条件

分子量	528.54
分子式	C23H24N6O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-Methoxypyridin-3-yl)-3-nitro-4-(4-(3-nitrobenzyl)piperazin-1-yl)benzenesulfonamide

参考文献

1. Pan Chen, et al. J Med Chem. 2023 May 25;66(10):6938-6958.

MyD88 inhibitor C17 (MyD88-IN-1)

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物理化学性质&存储条件

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MyD88 inhibitor C17 (MyD88-IN-1)

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物理化学性质&存储条件

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