MyD88 inhibitor 3g

Chemical Structure : MyD88 inhibitor 3g

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货号: PC-25527Not For Human Use, Lab Use Only.

MyD88 inhibitor 3g is a potent, TIR domain-selective and orally bioavailable MyD88 inhibitor, binds TIR domain (SPR KD=28.5 uM) but not the DD domain, disrupts MyD88 dimerization.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MyD88 inhibitor 3g is a potent, TIR domain-selective and orally bioavailable MyD88 inhibitor, binds TIR domain (SPR KD=28.5 uM) but not the DD domain, disrupts MyD88 dimerization.
MyD88 inhibitor 3g significantly suppressed IL-6 secretion from J774A.1 cells (IC50 = 1.32 μM) and THP-1 cells (IC50 = 0.75 μM). MyD88 inhibitor 3g inhibited the activation of the NF-κB and MAPK pathways stimulated by LPS.
MyD88 inhibitor 3g exhibited anti-inflammatory function by binding to the TIR domain instead of the DD domain.
MyD88 inhibitor 3g demonstrated significant anti-inflammatory efficacy and offered substantial protection against LPS and CLP-induced ALI.

物理化学性质&存储条件

分子量	508.55
分子式	C24H24N6O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(4-Cyanobenzyl)piperazin-1-yl)-N-(6-methoxypyridin-3-yl)-3-nitrobenzenesulfonamide

参考文献

1. Pan Chen, et al. J Med Chem. 2025 Sep 12. doi: 10.1021/acs.jmedchem.5c01786.