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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Mutant KCNJ5 agonist C105
Mutant KCNJ5 agonist C105

Chemical Structure : Mutant KCNJ5 agonist C105

CAS No.: 696650-92-7

Mutant KCNJ5 agonist C105

货号: PC-27765Not For Human Use, Lab Use Only.

Mutant KCNJ5 agonist C105 is a selective, first-in-class mutant KCNJ5 (GIRK4) agonist, increases mutant KCNJ5-induced cell death in adrenal cells, without affecting cells expressing wild-type KCNJ5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Mutant KCNJ5 agonist C105 is a selective, first-in-class mutant KCNJ5 (GIRK4) agonist, increases mutant KCNJ5-induced cell death in adrenal cells, without affecting cells expressing wild-type KCNJ5.

物理化学性质&存储条件

分子量 466.87
分子式 C24H17ClF2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2'-amino-6-chloro-1'-[2,4-difluorophenyl]-7-methyl-2,5'-dioxo-1,2,5',6',7',8'-hexahydro-1'H-spiro[indole-3,4'-quinoline]-3'-carbonitrile

参考文献

1. Mir-Bashiri S, et al. Hypertension. 2026 Aug 17. doi: 10.1161/HYPERTENSIONAHA.126.27181.

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