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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Mtb IMPDH2-IN-2
Mtb IMPDH2-IN-2

Chemical Structure : Mtb IMPDH2-IN-2

CAS No.: 1434517-02-8

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Mtb IMPDH2-IN-2

货号: PC-27279Not For Human Use, Lab Use Only.

MtbIMPDH2-IN-2 is a potent, selective Mycobacterium tuberculosis (Mtb) inosine 5'-monophosphate dehydrogenase 2 (MtbIMPDH2) inhibitor with IC50 of 12 nM, and MIC of 12 uM for Mtb, blocks the biosynthesis of guanine nucleotides.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MtbIMPDH2-IN-2 is a potent, selective Mycobacterium tuberculosis (Mtb) inosine 5'-monophosphate dehydrogenase 2 (MtbIMPDH2) inhibitor with IC50 of 12 nM, and MIC of 12 uM for Mtb, blocks the biosynthesis of guanine nucleotides.

物理化学性质&存储条件

分子量 428.27
分子式 C21H15Cl2N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S)-2-(2,3-Dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]propanamide

参考文献

1. Chacko S, et al. J Med Chem. 2018;61(11):4739-4756.

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