Mtb GuaB2 inhibitor G9

Chemical Structure : Mtb GuaB2 inhibitor G9

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货号: PC-28179Not For Human Use, Lab Use Only.

Mtb GuaB2 inhibitor G9 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2) with IC50 of 0.94 nM, and potent MIC against virulent Mtb H37Rv (IC50=58 nM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Mtb GuaB2 inhibitor G9 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2) with IC50 of 0.94 nM, and potent MIC against virulent Mtb H37Rv (IC50=58 nM).
G9 shows high selectivity for bacterial GuaB over the human homology hIMPDH2 (hIMPDH2 IC50 >50 uM).
G9 is efficacious against Mycobacterium tuberculosis as a single agent and in combination with other antibiotics in the chronic C57BL/6, BALB/c, and C3HeB/FeJ mouse models of lung infection.

物理化学性质&存储条件

分子量	380.45
分子式	C21H24N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3s)-3-(4-((R)-1-((1,4-dihydro-2H-pyrano[3,4-c]quinolin-9-yl)oxy)ethyl)-1H-1,2,3-triazol-1-yl)-1-methylcyclobutan-1-ol

参考文献

1. Eric M. Kofoed, et al. Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis Infection. ACS Infect. Dis. (2026).