Mizagliflozin |CAS:666843-10-3 Probechem Biochemicals

Chemical Structure : Mizagliflozin

CAS No.: 666843-10-3

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Mizagliflozin (DSP-3235;KGA-3235;GSK-1614235)

货号: PC-61451Not For Human Use, Lab Use Only.

Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2.

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2 mg	￥1280	In stock
5 mg	￥1880	In stock
10 mg	￥3180	In stock
25 mg	￥5280	In stock
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100 mg		Get quote

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生物&药学活性

Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2.
Mizagliflozin increases stool frequency and loosens stool consistency in phase I study.
Mizagliflozin increases fecal wet weight in a dog model of loperamide-induced constipation and a rat model of low-fiber-diet-induced constipation, similar to lubiprostone.

物理化学性质&存储条件

分子量	564.68
分子式	C28H44N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((3-(4-((5-isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)-2,2-dimethylpropanamide

参考文献

1. Inoue T, et al. Eur J Pharmacol. 2017 Jul 5;806:25-31.

Mizagliflozin (DSP-3235;KGA-3235;GSK-1614235)

生物&药学活性

物理化学性质&存储条件

参考文献

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Mizagliflozin (DSP-3235;KGA-3235;GSK-1614235)

生物&药学活性

物理化学性质&存储条件

参考文献

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