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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-Mitoxantrone
Mitoxantrone

Chemical Structure : Mitoxantrone

CAS No.: 65271-80-9

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Mitoxantrone

货号: PC-24867Not For Human Use, Lab Use Only.

Mitoxantrone is a specific small molecule inhibitor of USP11 with IC50 of 3.15 uM, impacts PDA cell survival with an IC50<10 nM, also is a potent topoisomerase II inhibitor and inhibits protein kinase C (PKC) activity with IC50 of 8.5 uM.

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50 mg ￥450 In stock
100 mg ￥650 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mitoxantrone is a specific small molecule inhibitor of USP11 with IC50 of 3.15 uM, impacts PDA cell survival with an IC50<10 nM, also is a potent topoisomerase II inhibitor and inhibits protein kinase C (PKC) activity with IC50 of 8.5 uM.

物理化学性质&存储条件

分子量 444.49
分子式 C22H28N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione

参考文献

1. Burkhart RA, et al. Mol Cancer Res. 2013 Aug;11(8):901-11.

2. Jacko AM, et al. Cell Death Dis. 2016 Nov 17;7(11):e2474.

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