MitoSNO | Mitochondria S-nitrosating agent | Probechem Biochemicals

Chemical Structure : MitoSNO

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MitoSNO (Mitochondria-targeted S-nitrosothiol)

货号: PC-24382Not For Human Use, Lab Use Only.

MitoSNO (mitochondria-targeted S-nitrosothiol) is a mitochondria-selective S-nitrosating agent, selectively S-nitrosates mitochondrial proteins.

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生物&药学活性

MitoSNO (mitochondria-targeted S-nitrosothiol) is a mitochondria-selective S-nitrosating agent, selectively S-nitrosates mitochondrial proteins.
MitoSNO inhibits mitochondrial hydrogen peroxide (mtH2O2) generation by α-ketoglutarate dehydrogenase (KGDH)
MitoSNO also suppressed mtH2O2 production and partially rescued mitochondrial respiration in Huh-7 cells subjected to palmitate (PA) and fructose (Fruc) induced lipotoxicity.
MitoSNO protects against acute ischaemia/reperfusion (IR) injury by inhibiting the reactivation of mitochondrial complex I.

物理化学性质&存储条件

分子量	645.77
分子式	C31H40N3O6PS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phosphonium, [5-[[2-(acetylamino)-3-methyl-3-(nitrosothio)-1-oxobutyl]amino]pentyl]triphenyl-, methanesulfonate (1:1)

参考文献

1. Chouchani ET, et al. Biochem J. 2010 Aug 15;430(1):49-59.

2. Chouchani ET, et al. Nat Med. 2013 Jun;19(6):753-9.

3. Methner C, et al. Eur J Heart Fail. 2014 Jul;16(7):712-7.

MitoSNO (Mitochondria-targeted S-nitrosothiol)

生物&药学活性

物理化学性质&存储条件

参考文献

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MitoSNO (Mitochondria-targeted S-nitrosothiol)

生物&药学活性

物理化学性质&存储条件

参考文献

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