Mesinostat

Chemical Structure : Mesinostat

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货号: PC-25904Not For Human Use, Lab Use Only.

Mesinostat is a potent and selective HDAC6 inhibitor with IC50 of 7.7 nM, >200-fold selective over HDAC1.

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250 mg		Get quote

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生物&药学活性

Mesinostat is a potent and selective HDAC6 inhibitor with IC50 of 7.7 nM, >200-fold selective over HDAC1.
Mesinostat inhibits the growth of MDA-MB-231 cells with IC50 of 11 uM (48 h), induces α-tubulin acetylation. Mesinostat induces apoptosis in MDA-MB-231 cells.
Mesinostat significantly increases the expression of LC3II protein, promotes autophagy in human TNBC cells, induces cell cycle arrest.
Mesinostat suppresses epithelial-mesenchymal transition (EMT) in human TNBC cells, inhibits cell migration and colony formation.
Mesinostat (1-10 uM) reduces viability and stem-like properties in lymph node metastasis-derived TNBC organoids

物理化学性质&存储条件

分子量	412.47
分子式	C22H25FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-fluoro-N-hydroxy-4- ((8-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro [4.5]decan-3yl) methyl) benzamide

参考文献

1. Bello I, et al. Pharmacol Res. 2025 Dec 2;222:108055.

2. Barone S, et al. Eur J Med Chem. 2025 Aug 5;292:117634.

Mesinostat

生物&药学活性

物理化学性质&存储条件

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Mesinostat

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