Merck60 (BRD 6929) | HDAC1/2 inhibitor | ProbeChem Biochemicals

Chemical Structure : Merck60

CAS No.: 849234-64-6

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Merck60 (BRD-6929, BRD6929, Compound-60)

货号: PC-70123Not For Human Use, Lab Use Only.

Merck60 (BRD 6929, Compound-60) is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Merck60 (BRD 6929, Compound-60) is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively.
Merck60 displays 50-400 fold selectivity over class I HDAC3 (IC50 = 458 nM) and no appreciable inhibition of HDAC8 or of the class II HDACs (IC50>30 uM).
Merck60 alters gene expression in brain circuits involved in mood regulation, improves mood-related behaviors in mice.

物理化学性质&存储条件

分子量	351.424
分子式	C19H17N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide

参考文献

1. Schroeder FA, et al. PLoS One. 2013 Aug 14;8(8):e71323.

2. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.

3. Stubbs MC, et al. Clin Cancer Res. 2015 May 15;21(10):2348-58.

Merck60 (BRD-6929, BRD6929, Compound-60)

生物&药学活性

物理化学性质&存储条件

参考文献

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Merck60 (BRD-6929, BRD6929, Compound-60)

生物&药学活性

物理化学性质&存储条件

参考文献

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