Menadione sodium bisulfite (MSB) is a water-soluble form of vitamin K precursor menadione, suppresses prostate cancer growth by targeting the kinase VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3).
Menadione sodium bisulfite (MSB) is a water-soluble form of vitamin K precursor menadione, suppresses prostate cancer growth by targeting the kinase VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3). Menadione sodium bisulfite (MSB) directly oxidizes essential cysteines on class III PI 3-kinase VPS34, thus inactivating the PI(3)P-producing enzyme. Menadione sodium bisulfite (MSB) suppresses PC progression and induces oxidative stress. MSB triggers an oxidative cell death modality. Dietary MSB improved muscle histology and function and extended life span in a myotubular myopathy model.
物理化学性质&存储条件
分子量
276.24
分子式
C11H9NaO5S
外观性状
Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Menadione sodium bisulfite
参考文献
1. Swamynathan MM, et al. Science. 2024 Oct 25;386(6720):eadk9167.
