Mebendazole

Chemical Structure : Mebendazole

CAS No.: 31431-39-7

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货号: PC-45379Not For Human Use, Lab Use Only.

Mebendazole is a highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells..

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生物&药学活性

Mebendazole is a highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.
Mebendazole modulates gravitropic set-point angle (GSA) in Arabidopsis thaliana roots and acts via the activation of ethylene signaling.
Mebendazole directly acts on the serine/threonine protein kinase CTR1, which is a negative regulator of ethylene signaling.
Mebendazole inhibits Hedgehog pathway and tubulin polymerization, also is a potent inhibitor targeting Novel Organic Cation Transporter 1 (OCTN1), effectively suppressing the proliferation of cervical and lung cancer cells.

物理化学性质&存储条件

分子量	295.2927
分子式	C16H13N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 23 mg/mL
Chemical Name/SMILES	Carbamic acid, N-(6-benzoyl-1H-benzimidazol-2-yl)-, methyl ester

参考文献

1. Xu B, et al. Nat Commun. 2026 Sep 14;17(1):10799.

Mebendazole

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