Mazdutide TFA (IBI362, LY3305677) | GCGR/GLP-1 agonist

Chemical Structure : Mazdutide TFA

CAS No.:

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Mazdutide TFA (IBI-362, LY-3305677, OXM-3)

货号: PC-28373Not For Human Use, Lab Use Only.

Mazdutide TFA (IBI362, LY3305677) is a synthetic peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor (GCGR), binds human and mouse GCGR (Ki=17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki=28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50=5.2 nM).

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Mazdutide TFA (IBI362, LY3305677) is a synthetic peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor (GCGR), binds human and mouse GCGR (Ki=17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki=28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50=5.2 nM).

物理化学性质&存储条件

分子量	4563.06 (free base)
分子式	C210H322N46O67.Xc2hf3o2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2 TFA

参考文献

1. Jiang H, et al. Nat Commun. 2022 Jun 24;13(1):3613.

2. Ji L, et al. Nat Commun. 2023 Dec 14;14(1):8289.

Mazdutide TFA (IBI-362, LY-3305677, OXM-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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Mazdutide TFA (IBI-362, LY-3305677, OXM-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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