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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-Magnoflorine iodide
Magnoflorine iodide

Chemical Structure : Magnoflorine iodide

CAS No.: 4277-43-4

Magnoflorine iodide ((+)-Magnoflorine iodide)

货号: PC-27799Not For Human Use, Lab Use Only.

Magnoflorine iodide ((+)-Magnoflorine iodide) is a dietary alkaloid from Alpinia oxyphylla fruit within anxiolytics, anti-cancer, and anti-inflammatory properties, inhibits the activation of NF-κB and MAPK signaling pathways.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Magnoflorine iodide ((+)-Magnoflorine iodide) is a dietary alkaloid from Alpinia oxyphylla fruit within anxiolytics, anti-cancer, and anti-inflammatory properties, inhibits the activation of NF-κB and MAPK signaling pathways.
Magnoflorine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibiting JAK2/STAT3 signaling pathway.
Magnoflorine increases transforming growth factor β-induced factor 1 (TGIF1) transcriptional activity by promoting ubiquitination and degradation of KDM3A, thus inhibiting the activation of TGF-β1/Smad2/3 signaling.
Magnoflorine attenuates Ang II-induced cardiac remodeling via promoting AMPK-regulated autophagy.

物理化学性质&存储条件

分子量 469.32
分子式 C20H24INO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1,11-Dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium iodide

参考文献

1. Zhang M, et al. Heliyon. 2024 Nov 8;10(22):e39892.

2. Zhu M, et al. Cardiovasc Diagn Ther. 2024 Aug 31;14(4):576-588.

3. Wang L, et al. J Inflamm Res. 2023 May 27;16:2271-2296.

4. Chang L, et al. Front Physiol. 2020 Dec 22;11:580406.

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