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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Other Viruses-MWAC-3475
MWAC-3475

Chemical Structure : MWAC-3475

CAS No.: 300829-23-6

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MWAC-3475 (MWAC3475)

货号: PC-26469Not For Human Use, Lab Use Only.

MWAC-3475 is a potent small molecule Zika virus (ZIKV) inhibitor targeting the viral protein NS4B with EC50 of 0.63 uM in CPE-based assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MWAC-3475 is a potent small molecule Zika virus (ZIKV) inhibitor targeting the viral protein NS4B with EC50 of 0.63 uM in CPE-based assays.
MWAC-3475 shows no activity against other flaviviruses, including DENV, Yellow fever virus (YFV), Japanese encephalitis virus (JEV), and West Nile virus (WNV).
MWAC-3475 induces significant, concentration-dependent, reduction in progeny virus titers, > 1000-fold reduction at 5 µM and reaching a 4.2-log reduction (or 1.78 x 10 4-fold) at 20 µM in ZIKV- infected Vero 76 cells.
MWAC-3475 inhibits viral replication in the middle stage and require de novo protein synthesis.

物理化学性质&存储条件

分子量 245.37
分子式 C16H23NO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(tert-butyl)-N-cyclopentylbenzamide

参考文献

1. Chung D, et al. PLoS Pathog. 2026 Apr 3;22(4):e1013609.

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