MW073 | 5-HT2bR inhibitor | Probechem Biochemicals

Chemical Structure : MW073

加入收藏

MW073 (MW-073)

货号: PC-24324Not For Human Use, Lab Use Only.

MW073 is a highly selective and orally bioavailable inhibitor of 5-HT2b receptor (5-HT2bR) with binding IC50 of 70 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MW073 is a highly selective and orally bioavailable inhibitor of 5-HT2b receptor (5-HT2bR) with binding IC50 of 70 nM.
MW073 is serotonin 5-HT2bR activation and β-arrestin-1 recruitment with Kd of 89 nM for m5-HT2bR and 125 nM for h5-HT2bR, and Kb value of m5-HT2bR (73 nM) and h5-HT2bR (102 nM).
MW073 also inhibits basal constitutive activity for both species of 5-HT2bR.
MW073 exhibited only 5-HT2bR antagonist activity when subjected to large-scale cellular screening of 165 diverse GPCRs for agonist and antagonist activity.
MW073 protects against long-term potentiation (LTP) reduction by Aβ and tau oligomers.
MW073 ameliorates the RAWM and FC defects in a dose-dependent manner in APP/PS1 mice.
MW073 attenuates synaptic and behavioral dysfunctions an animal models of neuropsychatric syndromes.

物理化学性质&存储条件

分子量	361.49
分子式	C22H27N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methyl-N-(2-(4-methylpiperazin-1-yl)ethyl)-6-(naphthalen-2-yl)pyridazin-3-amine

参考文献

1. Roy SM, et al. Alzheimers Dement (N Y). 2025 Mar 27;11(1):e70073.

MW073 (MW-073)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MW073 (MW-073)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.