MU147 | MRE11 inhibitor | Probechem Biochemicals

Chemical Structure : MU147

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MU147 (MU-147)

货号: PC-23727Not For Human Use, Lab Use Only.

MU147 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 25.3 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination.

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生物&药学活性

MU147 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 25.3 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination.
MU147 inhibits MRE11 nuclease more specifically and effectively than mirin.
MU147 shows good selectivity against MUS81 and EXO1 (IC50>200 uM), but not FEN1(IC50=82.7 uM) in in vitro nuclease activity assays.
MU147 is significantly more effective at inhibiting exonuclease activity of MRE11 compared to mirin analog PFM01 in in vitro gel-based assays.
MU147 blocks MRE11 nuclease and affect DNA repair in cells.

物理化学性质&存储条件

分子量	363.39
分子式	C19H13N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylthiazol-2-yl)acrylamide

参考文献

1. Nikulenkov F, et al. Eur J Med Chem. 2025 Jan 1;285:117226.

MU147 (MU-147)

生物&药学活性

物理化学性质&存储条件

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MU147 (MU-147)

生物&药学活性

物理化学性质&存储条件

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