MTHFD2 inhibitor 31

Chemical Structure : MTHFD2 inhibitor 31

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货号: PC-26406Not For Human Use, Lab Use Only.

MTHFD2 inhibitor 31 is a potent, highly selective MTHFD2 inhibitor with IC50 of 38 nM, >180-fold selective over MTHFD1 (IC50=7440 nM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MTHFD2 inhibitor 31 is a potent, highly selective MTHFD2 inhibitor with IC50 of 38 nM, >180-fold selective over MTHFD1 (IC50=7440 nM).
MTHFD2 inhibitor 31 exhibits dose-dependent inhibition of cell viability across five leukemia cell lines MOLM-13, THP-1, K562, NALM-6, and MOLT-4 cells with IC50 of 0.25 uM-4.75 uM.
MTHFD2 inhibitor 31 induced modest, dose-dependent inhibition, with tumor growth inhibition of 37% at 100 mg/kg and 67% at 300 mg/kg in MOLM-13 xenograft mouse model.

物理化学性质&存储条件

分子量	623.65
分子式	C28H32F3N5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-(8-(3,4-Dimethylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(trifluoromethoxy)phenyl)-N-methylsulfuric Diamide

参考文献

1. Hao Lin, et al. J Med Chem. 2026 Mar 20. doi: 10.1021/acs.jmedchem.6c00023.