MTEP

Chemical Structure : MTEP

CAS No.: 329205-68-7

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货号: PC-26041Not For Human Use, Lab Use Only.

MTEP is a potent, selective, non-competitive mGlu5 antagonist with IC50 of 5 nM and Ki of 16 nM.

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生物&药学活性

MTEP is a potent, selective, non-competitive mGlu5 antagonist with IC50 of 5 nM and Ki of 16 nM.
MTEP produces antidepressant effects in several rodent models of depression.
MTEP also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage.

物理化学性质&存储条件

分子量	200.26
分子式	C11H8N2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-4-(pyridin-3-ylethynyl)thiazole

参考文献

1. Busse CS, et al. Neuropsychopharmacology. 2004 Nov;29(11):1971-9.

2. Keck TM, et al. ACS Med Chem Lett. 2012 Jul 12;3(7):544-549.

3. Rasmussen K, et al. Neuropharmacology. 2005 Feb;48(2):173-80.

MTEP

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MTEP

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