MT-SYK-03

Chemical Structure : MT-SYK-03

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货号: PC-26203Not For Human Use, Lab Use Only.

MT-SYK-03 is selective orally available inhibitor of cSrc and SYK kinases, inhibits cSrc and SYK with IC50 of 14.2 and 23 nM respectively.

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生物&药学活性

MT-SYK-03 is selective orally available inhibitor of cSrc and SYK kinases, inhibits cSrc and SYK with IC50 of 14.2 and 23 nM respectively.
MT-SYK-03 at 500 nM inhibits 34 kinases by more than 50%, 13 kinases by more than 80% and only five kinases by more than 90% in a panel of 341 protein kinases.
MT-SYK-03 effectively suppresses osteoclast-mediated bone resorption and inhibits degradation of aggrecan and type II collagen in chondrocytes.
MT-SYK-03 dose-dependently inhibits anti-IgM induced autophosphorylation of SYK kinase, phosphorylation of downstream B-cell signaling cascade components CD19 and BTK, as well as components of MAP cascade (ERK1/2 and JNK1/2).
MT-SYK-03 inhibits BCR-dependent (but not PMA-dependent) activation of B cells with IC50 of 0.55 uM, inhibits TNF-α release in monocytes with IC50 of 0.48 uM.
MT-SYK-03 shows anti-resorptive effects on cartilage in surgically induced meniscal tear OA in rats.
MT-SYK-03 alleviates inflammation and cartilage damage in murine CIA.

物理化学性质&存储条件

分子量	453.46
分子式	C21H23N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2-dimethyl-6-((4-((3,4,5-trimethoxyphenyl)amino)-1,3,5-triazin-2-yl)amino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

参考文献

1. Zeifman AA, et al. Mendeleev Commun. 2012;22:73–74.

2. F N Novikov, et al. Sci Rep. 2021 Nov 30;11(1):23120.

MT-SYK-03

生物&药学活性

物理化学性质&存储条件

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MT-SYK-03

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物理化学性质&存储条件

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