MT-125 | non-muscle myosin II inhibitor | Probechem Biochemicals

Chemical Structure : MT-125

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MT-125 (MT125)

货号: PC-24862Not For Human Use, Lab Use Only.

MT-125 is a specific, brain penetrant small-molecule inhibitor of non-muscle myosin IIA and IIB (NMIIA and IIB) with Ki of 2.7 uM (NMIIA) and EC50 of 1.7 uM (NMIIB).

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生物&药学活性

MT-125 is a specific, brain penetrant small-molecule inhibitor of non-muscle myosin IIA and IIB (NMIIA and IIB) with Ki of 2.7 uM (NMIIA) and EC50 of 1.7 uM (NMIIB).
MT-125 has very limited activity against cardiac myosin II (CMII; KI,CMII = 50 uM).
MT-125 blocks GBM invasion and cytokinesis, and prolongs survival in murine GBM models.
MT-125 increases redox stress and consequent DNA damage, and synergizes with radiotherapy.
MT-125 also induces oncogene addiction to PDGFR signaling through a mechanism that is driven by redox stress, and it synergizes with FDA-approved PDGFR and mTOR inhibitors in vitro.
Combining MT-125 with sunitinib, a PDGFR inhibitor, or paxalisib, a combined phosphatidylinositol 3-kinase (PI3K)/mTOR inhibitor, significantly improves survival in orthotopic GBM models over either drug alone.

物理化学性质&存储条件

分子量	357.41
分子式	C22H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3a-hydroxy-6-methyl-1-(2-methylquinolin-6-yl)-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one

参考文献

1. Kenchappa RS, et al. Cell. 2025 Jun 3:S0092-8674(25)00569-0.

MT-125 (MT125)

生物&药学活性

物理化学性质&存储条件

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MT-125 (MT125)

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