MST3 inhibitor LD-1

Chemical Structure : MST3 inhibitor LD-1

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货号: PC-24897Not For Human Use, Lab Use Only.

MST3 inhibitor LD-1 is a potent, selective inhibitor of MST3 protein kinase (mammalian Ste20-like protein kinase 3, STK24) with IC50 of 122.4 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MST3 inhibitor LD-1 is a potent, selective inhibitor of MST3 protein kinase (mammalian Ste20-like protein kinase 3, STK24) with IC50 of 122.4 nM.
LD-1 displays weak to no activity against homologous kinases YSK1, MST1, and MST2.
shows antiproliferative activities against HepG2, HCT116, H226 cancer cells with GI50 of 0.68-0.83 uM.
LD-1 (0.5-1 uM) induced apoptosis, inhibits the proliferation of HepG2 cells.
LD-1 (40 mg/kg, oral) exhibits antitumor effect on HepG2 xenograft mouse model.

物理化学性质&存储条件

分子量	547.53
分子式	C25H21F4N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)-1,4-dihydroquinoline-3-carboxamide

参考文献

1. Deping Li, et al. Eur J Med Chem. 2025 Jun 28:297:117923.