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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-MSC-4106
MSC-4106

Chemical Structure : MSC-4106

CAS No.: 2738542-58-8

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MSC-4106 (MSC4106)

货号: PC-47086Not For Human Use, Lab Use Only.

MSC-4106 is a potent, in vivo active inhibitor of TEAD transcription factor with IC50 of 4 and 14 nM in SK-HEP1 reporter and NCI-H226 viability assays, respectively.

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5 mg ￥2380 In stock
10 mg ￥3880 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MSC-4106 is a potent, in vivo active inhibitor of TEAD transcription factor with IC50 of 4 and 14 nM in SK-HEP1 reporter and NCI-H226 viability assays, respectively.
MSC-4106 binds to TEAD P-site.
MSC-4106 exhibits desirable potency, mouse pharmacokinetic properties, and in vivo efficacy.

物理化学性质&存储条件

分子量 359.308
分子式 C18H12F3N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-methyl-8-(4-(trifluoromethyl)phenyl)-2,8-dihydropyrazolo[3,4-b]indole-5-carboxylic acid

参考文献

1. Heinrich T, et al. J Med Chem. 2022 Jun 28. doi: 10.1021/acs.jmedchem.2c00403.

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